Every 'Grey's Anatomy' Series Regular Actor Who Left the Show, From First to Most Recent

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Grey’s Anatomy is one of the most popular TV shows of all time and it’s approaching season 20 on ABC. Ellen Pompeo, the long-running star of the series, left the show in the middle of season 19.

Throughout the last two decades, there have been more than 20 series regular actors who have left the series after spending many years at Grey Sloan Memorial Hospital. Head inside to see all of the series regular actors who have left Grey’s Anatomy… Keep scrolling to see all of the series regular actors who have left Grey’s Anatomy… Isaiah Washington Character: Preston BurkeSeasons on Show: 3Left After: Season 3 Kate Walsh Character: Addison MontgomerySeasons on Show: 2 as series regularLeft After: Season 3 (returned for guest appearances through season 8) Brooke Smith Character: Erica HahnSeasons on Show: 2 as series regularLeft After: Season 5 T.

R. Knight Character: George O’MalleySeasons on Show: 5Left After: Season 5 (later returned for a guest appearance) Katherine Heigl Character: Izzie StevensSeasons on Show: 6Left After: Season 6 Chyler Leigh Character: Lexie GreySeasons on Show: 5 as series regularLeft After: Season 8 (later returned for a guest appearance) Eric Dane Character: Mark SloanSeasons on Show: 7 as series regularLeft After: Season 9 (later returned for a guest appearance) Sandra Oh Character: Cristina YangSeasons on Show: 10Left After: Season 10 Gaius Charles Character: Shane RossSeasons on Show: 1 as series regularLeft After: Season 10 Tessa Ferrer Character: Leah MurphySeasons on Show: 1 as series regularLeft After: Season 10 (returned as recurring in season 13) Patrick Dempsey Character: Derek ShepherdSeasons on Show: 11Left After: Season 11 (later returned for a guest appearance) Sara Ramirez Chara