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Meredith Grey
Alex Karev
Cristina Yang
The Most Devastating ‘Grey’s Anatomy’ Breakups of All Time, Including Multiple Meredith Splits
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usmagazine.comGrab a box of tissues and prepare for sappy voiceovers. Meredith Grey, Alex Karev, Cristina Yang and more Grey’s Anatomy characters — past and present — have been through the romantic ringer since the show began in March 2005.The ABC drama’s leading lady, Meredith (Ellen Pompeo), has had it particularly rough, given her on-again, off-again relationship with Derek Shepherd (Patrick Dempsey) and his eventual tragic death.In fact, several Grey’s Anatomy splits stemmed from the actors’ decisions to depart the series. “In order for a one-hour drama to continue, there has to be big upheavals,” Pompeo told Us Weekly in August 2015. “Every time we’ve lost a major character — we’ve had such amazing characters on the show and every time we’ve lost
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