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‘Grey’s Anatomy’ Reunites Alex Karev and Izzie Stevens After Justin Chambers’ Exit: Revisit Their Relationship Timeline

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True love! It’s been more than a decade since Katherine Heigl appeared on Grey’s Anatomy, but her character, Izzie Stevens, was a major part of Justin Chambers’ departure from the series in March 2020.Chambers, who played Alex Karev for 16 seasons on the ABC medical drama, announced his departure from the show in November 2019.

While he last appeared on the series that month, he returned for a voiceover to close the character’s story arc. During the March 5, 2020, episode, viewers learned that Alex left his wife, Jo Wilson (Camilla Luddington), to be with Izzie and their twins, whom she secretly welcomed without Alex knowing.

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