is back with new castaways vying for the $1 million prize on season 43.The long-running CBS reality staple will introduce 18 new castaways who will attempt to outplay and outwit each other to earn the title of Sole Survivor.

The upcoming edition, hosted by Jeff Probst, kicks off with a two-hour premiere Wednesday, Sept. 21 at 8 p.m. ET/PT. The latest hopefuls include competitors from various backgrounds and parts of the country, including a 31-year-old clinical psychologist and a 24-year-old UX designer to a 30-year-old with a Ph.D.

in political science and a 25-year-old U.S. Paralympian. According to CBS, season 43 will «launch a new chapter with thrilling elements» that will keep the castaways — who «bring a fresh perspective to this new era of the game — on their toes.

The new season marks 's 22 years on TV, with nearly 650 castaways and torch snuffs. The premiere episode marks the franchise's 621st hour.Meet the 18 castaways below.

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Miami Texas state Hawaii Florida state Pennsylvania state Massachusets county San Diego state Utah San Francisco county Durham state Georgia state Iowa state North Carolina Austin, state Texas city Venice county Palo Alto county Preston Philadelphia, state Pennsylvania county Hamilton Honolulu, state Hawaii state Delaware city Salt Lake City, state Utah city Atlanta, state Georgia city Plano, state Texas city Honolulu, state Hawaii city Newark, state Delaware city Philadelphia, state Pennsylvania Jeff Probst Marina Del Rey U.S.Paralympian Cassidy Clark Cody Assenmacher Dwight Moore Justine Brennan Cruz Godoy stars country Survivor

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'Survivor' Reveals the Season 43 Cast: Meet the 18 Castaways

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