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Rob Lowe Has No Regrets About Turning Down ‘Grey’s Anatomy’

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A couple years back, Rob Lowe revealed that he was offered the role of Derek “McDreamy” Shepherd, but turned it down. “That’s probably cost me $70 million,” he joked during a 2019 appearance on Mark Maron’s “WTF” podcast.

In a new interview with Variety, Lowe explains he has no regrets about turning down the role in the mega-hit medical drama that ultimately went to Patrick Dempsey.

RELATED: Rob Lowe Reveals He Turned Down Playing McDreamy On ‘Grey’s Anatomy’, Jokes That It ‘Probably Cost Me $70 Million’ As Lowe explained, he simply didn’t feel the role was a good fit. “Me in that part isn’t as interesting as Patrick in that part,” he said. “If it’d been me [the fans] wouldn’t have called me ‘McDreamy,’ they would have called me Rob Lowe.”

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